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In all such interaction networks, most proteins interact with one or only a few other proteins These networks are essential for. However, a relatively small number of proteins (hubs) have a very large number of interacting partners, reaching tens and even hundreds.

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Advances in understanding cellular ppis have gone lock step with technological innovations (figure 1). Our method first generates a set of proximity scores between a protein interaction and sets of cause and effect proteins using a network propagation procedure. Download scientific diagram | the protein and protein interaction networks of all differentially expressed proteins.

In this work, we propose a novel deep learning approach for ppi network orientation